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Custom Development & Manufacturing Services

One-Stop Custom Development & Manufacturing

Yuhan offers comprehensive contract manufacturing services with the promise of quality, consistency, and reliability.

Equipped with excellent research capabilities and cGMP manufacturing facilities with approvals by United States’ Food & Drug Administration (FDA), the European Directorate for the Quality of Medicines (EDQM), Australia’s Therapeutic Goods Administration (TGA), Japan’s Pharaceuticals and Medical Devices Agency (PMDA), and other regulatory agencies, Yuhan develops safe, robust, economical and value-added processes for production and delivery.

Yuhan excels in the custom synthesis marketplace as a one-stop service provider offering early process development
through commercial supply. Yuhan’s one-stop services offer numerous benefits to customers which may ultimately
translate into improved product quality, more efficient processes, and significant savings of time and money.

Yuhan Offers:

  • Custom Manufacturing
  • Process Research and Development of APIs and intermediates
  • Kilo and pilot-scale production of APIs and intermediates
  • Commercial production of APIs and intermediates
  • Production of chemical specialties
  • Analytical method development and regulatory support

Customer Benefits:

  • One-stop project management from early development to commercial supply
  • Dedicated project management team with communication proximity
  • Robust and economical process development with sound chemistry
  • Quality guaranteed production
  • Assurance of intellectual property protection
  • Rigid adherence to deadlines
  • Customer - oriented and reliable partnership

Manufacturing Capabilities:

Manufacturing Capabilities
C-C Bond formation
  • Suzuki coupling, Sonogashira coupling
  • Wittig reaction, Julia-Kocienski Olefination
  • Modified Buchwald-Hartwig cross-coupling
  • Cyclopropanation via dialkylation
Bond formation
  • Amide coupling with various activating agents
  • Glycosidation with pyrimidine and purine derivatives
  • Sulfide formation with thiol
Chiral Technology
  • Enzymatic resolution
  • Diastereomeric crystallization
  • Synthesis using Chiral Auxiliary
  • Asymmetric reduction
Aromatic Ring
  • Friedel-Craft Acylation, Sugasawa reaction
  • Halogenation using NIS, NCS
Reduction & Oxidation
  • Catalytic Hydrogenation(max 10 bar)
  • Various metal hydride reduction(NaBH4, LAH, LTTBA, Red-Al etc)
  • Ozonolysis
  • Various oxidation with TEMPO, DDQ, MCPBA and H2O2
  • Aziridine, Pyrrolidine, Imidazole, Pyrimidine, Quiniline & Purines
Hazardous Chemical
Handled at Plant scale
  • Methylating agent: CH3I, CH3MgCl, iPrMgCl etc
  • Strong organometallic bases: BuLi, LiHMDS and n-HexLi
  • In situ generation of Borane(BH3)
  • Azidation: NaN3 & DPPA
  • Functional group transformation
  • Protecting group Chemistry
  • PEGylation