Yuhan Corporation has one of the largest research facilities among all Korean pharmaceutical firms.
The Central Research Instistute operates a number of cutting-edge equipment and facilities, including those that
are essential for the exploration of candidates for new drugs and evaluation of their efficacy. NMR spectrometers,
LC-MS, XRD, AKTA Avant 150 and cell culture labs are also in place. Equipment for research on new product form
(such as multi-layer tablet press machine or one-pots), IVIS spectrum analyzing device and animal testing equip-
ment as approved of by the regulatory authorities all add to the arsenal of Yuhan's R&D capabilities.
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LC-MS lab
Use for quantitative and qualitative analysis of API and
metabolite in bio-sample.
Model; Q-Tof premier LC/MS/MS System (Waters), Q-Trap
4000 LC/MS/MS System (AB Sciex), Agilent 6460 LC/MS/MS
System (Agilent)
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XRD
Use for analyzing the crystal structure of the materials and
chemical information
model; Bruker AXS / D8 Advance
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Protein refinement system
Bio-laboratory to isolation and purification of the protein
product Consist of AKTA purifier, AKTA Avant, and AKTA
pilot
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One-pot
Equipment that combines different unit operations of a
pharmaceutical production process into one machine, to
use for development of new solid formulations,
model; VMA10
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NMR Spectrometer
Use for evaluation of chemical structure of the active phar-
maceutical ingredients.
Model ; Bruker Avance(400 MHz), and Agilent PremiumCOMPACT(600 MHz)
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Cell culture lab
Bio-laboratory to research and development the cell-line
and production process for novel bio-product
Consist of clean bench, CO2 incubator, cell counter, me-
tabolite analyzer and bio-reactor (3-200L)
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multi-layer tablet press machine
Use for development of new pharmaceutical formulation
such as multi-layer tablet
Model; FlexiTab
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Sample analysis lab
Animal facilities to evaluation of PK profiles such as
absorption, distribution, metabolism and excretion of drug
candidate in animal model
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IVIS Spectrum
In vivo imaging system by use optical imaging technology
to facilitate non-invasive longitudinal monitoring cell and
drug trafficking in living animals
Model; PerkinElmer IVIS spectrum